Cecropin, antimicrobial peptides, peptide price, antimicrobial products, cecropin antimicrobial peptides, peptide applications, antimicrobial peptides manufacturers, peptide price, antimicrobial feed, feed antimicrobial peptides, natural antimicrobial peptides, plant antimicrobial peptides, peptide antibiotics, antimicrobial peptides company peptide manufacturers, antimicrobial peptides enterprises, pig antimicrobial peptides, antimicrobial feed additives antimicrobial peptides (Antimicrobial Peptides) is widespread in the biosphere of a class of biologically active small peptides, are benign molecules likely to result The novel anti-microbial infection drug resistance polypeptide. Found in the world's first antimicrobial peptides cecropins, 1980 by the Swedish scientist Boman other communication with Yin and E. coli bacteria induce pity Gumby day pupa produce antibacterial activity of peptide material, known as cecropins (cecropins). Then in other organisms have been discovered a variety of antimicrobial peptides, such as bombesin (magainins), melittin (melittins) defensins (defensins) and so on. The world's total of more than 1200 kinds of known antimicrobial peptides. Peptide 1 cecropin peptide is characterized cecropin and cecropin D design cecropin A 37 amino acid synthetic peptide hybrid, excluding cysteine, the N-terminal region has a strong basicity, can form a near-perfect parents helical structure in the C-terminal hydrophobic region may be formed in the spiral, between glycine and proline formed in the hinge region, the majority of the polypeptide is amidated C-terminal amidation of its antibacterial activity has an important role. The peptide molecule has a unique broad-spectrum antimicrobial activity, in vitro tests have proved that it can effectively inhibit E. coli, Staphylococcus aureus, salmonella and other harmful bacteria, so that it becomes an excellent choice for antibiotic alternatives one. As the research work in depth and found that some of the peptides would some fungi, protozoa, viruses, and cancer cells has a strong killing effect etc., and in other areas as well and has good application prospects. 2 mechanism of action of antimicrobial peptides cecropin and features 2.1 cecropin mechanism of action of antimicrobial peptides cecropin peptide molecules can be perforated in the bacterial cytoplasmic membrane to form an ion channel, resulting in bacterial cell membrane structural damage caused by a large number of intracellular water-soluble substances leaking, eventually leading to bacterial death. Cecropin first binding peptide molecules on the plasma membrane, in its molecule a hydrophobic end and amphipathic α-helix into the film, the more peptide molecules together to form ionic channels, loss of membrane potential of the bacteria die. This process is generally accepted by most scholars. This is exactly with penicillin and other antibiotics on bacterial traditional essence of different mechanisms of action. And cecropin peptides with broad spectrum antibacterial activity and inhibition to kill drug-resistant strains, etc., fungi, viruses and protozoa are also inhibited and killed the role of the innate immune system is the body part, with microorganisms can improve the body's innate defense response biological activity. 2.2 Mechanism of cecropin peptides characterized 2.2.1 site of action to eliminate the effectiveness of traditional antibiotics is necessary for microbial growth or survival functions, such as to block the bacterial protein synthesis activity or change to achieve sterilization purposes, and the bacteria by changing the a gene is sufficient to deal with antibiotics such attack. Cecropin antimicrobial peptides acting on the bacterial cell membrane, leading to increased membrane permeability, thus penetrate to kill bacteria. Bacterial membrane structure must be changed, that change can be a considerable part of the gene Cecropin antimicrobial peptides offensive defense, which is almost impossible. Therefore, cecropin antimicrobial peptides greatly reduces the possibility of resistance. 2.2.2 The role of the object of selective antimicrobial peptides cecropins only diseased cells prokaryotic and eukaryotic cells have an antibacterial effect, no effect on the normal eukaryotic cells. The reason is that the cell membrane structure prokaryotes and eukaryotes different eukaryotic cell contains a large amount of cholesterol, and cholesterol in the presence of the membrane structure is stable. In addition there is a highly developed higher animals cytoskeletal system, its existence also resisted the role of antimicrobial peptides. The skeletal system cancer cells compared with normal cells and underdevelopment are antimicrobial peptides inhibit one of the reasons for its produce. 3 Product Background and Description for 863 projects "feed peptide molecules improvement and product development," the research results, "Creation and antimicrobial peptides cecropins application technology research" results on January 8, 2009 by the Ministry of Education expert appraisal concluded that the project technology has reached the international advanced level. Has applied for national invention patent and international PCT patent. Items Bacillus subtilis as a host, using recombinant protein technology to transform the industrial production that can be created cecropin antimicrobial peptide production technologies, which is characterized as follows: ① host strain used in the Ministry of Agriculture approved safety strains to overcome the Most home and abroad as the host bacterium Escherichia coli safety issues; ② high yield, the highest value reported in the literature as 9.5 times; ③ high antibacterial activity against Staphylococcus aureus minimum inhibitory concentration of 0.2 ug / ml; can be a good substitute chlortetracycline, bacitracin, neomycin guitar feed antibiotics, and the effect is excellent. ④ product physicochemical properties of stability, at a temperature of 65 ℃, PH 3-8 under the conditions of its antimicrobial activity still retained more than 85%, and for pepsin and trypsin stability; ⑤ Application effect, livestock survival rate increased 3-5 percentage points, feed conversion efficiency 5-7 percent, farmers increased by 12% or more cost-effective. Our marriage National Feed Engineering Technology Research Center, to achieve its industrial production, and carried out a large number of applied research, which marks cecropin peptides may be true as veterinary drugs and feed additives used in animal production. Currently, the company's products are divided into cecropins and peptides avidin two class system. Cecropin products mainly contain antimicrobial peptides cecropins is additive products; peptide hormone whose main component is an aggregate Cecropin antimicrobial peptides for animal health products, livestock into peptides with new music, new music peptides and other poultry products. Focus on the future direction of antimicrobial peptides related research will focus on the identification of novel antimicrobial peptides; physiologically active peptide functional studies; development of various antimicrobial peptides prepared a cost-effective production systems and so on. 4 products to use 4.1 cecropin direct use of the product to add it to the diet, mix immediately after feeding. Specific dose in Table 1. Table 1 Cecropin add objects using dose volume (g / t) application objects dosage (g / t) application objects dosage (g / t) piglets (creep-10Kg) 200-300 sows 20-50 fish Class 100-200 pig (10-30Kg) 100-200 50-100 crustacean meat finishing pigs 100-150 50-100 200-300 4.2 Danqin peptide 50-100 special aquatic products to use avidin 4.2.1 Cecropin (poultry private) use short-term use, directly add spices, water dose halved; 7 to 14 days of continuous use. Long-term use, the recommended dose halved. Specific dose in Table 2. Table 2 cecropin (poultry exclusive) use of dosage dose phase (ppm) stage dosage (ppm) meat - Early Brood 400-500 500-600 Egg and Poultry meat - Interim 300-400 300-500 Egg and poultry rearing - Late Danqin laying 200-300 200-300 4.2.2 cecropins (livestock exclusive) use of short-term use, directly add spices, drinking half dose, continuous use 7-14 days. Long-term use, the recommended dose halved. Specific dosage in Table 3. Table 3 cecropin (livestock exclusive) use of dosage dose phase (ppm) stage dosage (ppm) weaned piglets 600-800 400-600 200-400 finishing pigs sow 800-1000 weak and diseased pigs stiff Aberdeen herd boar 800-10005 Outlook 2000-3000 antimicrobial efficient, broad-spectrum antimicrobial resistance and potential anti-tumor activity and other characteristics, is a traditional antibiotics unparalleled advantages. Is expected to become a new application of antibacterial and anticancer drugs. Although there are still many antimicrobial peptides inadequacies and does not solve the problem, but we believe that, with the continued penetration of antimicrobial peptides, and the popularity of the practical application and clinical trials, antimicrobial peptides according to their distinctive and unique nature bactericidal mechanism must be able to human health and livestock production and other fields to play its important role for mankind to create greater value. Also believe that through our efforts, one day, to achieve so that the benefit of all antimicrobial peptides great initiative! Tel :0371-65631493 18937177856 QQ 402909763 Website: http://www.meild.com